phenytoin side effects

Other side effects include: hepatic necrosis, ataxia, confusion, constipation, depression, dizziness, drowsiness, fatigue, hypertrichosis, mental status changes, myasthenia, nervousness, numbness, tremor, tremor of hands, vertigo, excitement, irritability, mood changes, and restlessness. ([2006]): 3. Phenytoin is an Anti-epileptic Agent. If you notice any other effects, check with your healthcare professional. Call your doctor if you have any unusual problems while you are taking this medication. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Although not all of these side effects may occur, if they do occur they may need medical attention. This content does not have an Arabic version. • Phenytoin administration has been associated with toxic effects. Phenytoin is a potent inducer of hepatic drug-metabolizing enzymes. Inability to move the eyes DILANTIN may cause serious side effects, including: A serious, life-threatening disorder called Stevens-Johnson syndrome and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), which can be fatal; Softening of your bones (osteopenia, osteoporosis, and osteomalacia). The condition escalates to TEN when rashes reach over thirty percent of the body. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). A large literature database was compiled through the DIMDI computer database and the inspection of recent reviews. Do not take this medicine if you are suffering from impaired liver function. Take this medicine at the same time regularly for a better seizure control. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Commonly reported side effects of phenytoin include: congenital anomalies. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Applies to phenytoin: oral capsule extended release, oral suspension, oral tablet chewable. PHENYTOIN SODIUM EXTENDED Side Effects by Likelihood and Severity . What are the side effects of Dilantin (Phenytoin (Injection))? Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Phenytoin hypersensitivity can present as rashes or Phenytoin hypersensitivity syndrome (PHS). Phenytoin systemic 100 mg (BERTEK 560 BERTEK 560), We comply with the HONcode standard for trustworthy health information -, trouble with breathing, speaking, or swallowing, unsteadiness, trembling, or other problems with muscle control or coordination, increased blinking or spasms of the eyelid, shakiness in the legs, arms, hands, or feet, trembling or shaking of the hands or feet, twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs, uncontrolled twisting movements of the neck, trunk, arms, or legs, blistering, peeling, or loosening of the skin, red skin lesions, often with a purple center, sores, ulcers, or white spots on the lips or in the mouth, swollen, painful, or tender lymph glands in the neck, armpit, or groin, feeling of constant movement of self or surroundings, increased hair growth on the forehead, back, arms, or legs. Back to Top. The oldest anti-epilepsy drug on the market today, Dilantin carries with it many side effects, from folic acid deficiency to recurrent neuro-toxicity. If you experience any of the following symptoms, stop taking phenytoin and call your doctor: swelling of the face, eyes, throat, tongue, or lips; difficulty swallowing or breathing; Phenytoin may cause other side effects. As with most medication, side effects are associated with the use of Phenytoin. Schedule your appointment now for safe in-person care. Antiepileptic medications have been associated with an increased risk of suicidal thinking and behavior. Share. Phenytoin prevents the electrical spread of a focus of irritable tissue from entering normal tissue. Shopping. trouble with breathing, speaking, or swallowing, unsteadiness, trembling, or other problems with muscle control or coordination, increased blinking or spasms of the eyelid, shakiness in the legs, arms, hands, or feet, trembling or shaking of the hands or feet, twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs, uncontrolled twisting movements of the neck, trunk, arms, or legs, blistering, peeling, or loosening of the skin, numbness, tingling, or pain in the hands or feet, red skin lesions, often with a purple center, sores, ulcers, or white spots on the lips or in the mouth, swollen, painful, or tender lymph glands in the neck, armpit, or groin, feeling of constant movement of self or surroundings, increased hair growth on the forehead, back, arms, or legs. If you have epilepsy, it's best to stay on the same brand of phenytoin, as other brands may not work as well for you. This content does not have an English version. These may be avoidable if the dosage is increased slowly. Phenytoin has major effects on metabolism of other medications, and patients should be provided specific advice about other medications that can be used during long term phenytoin therapy. The most common side effects of DILANTIN include: Irregular movement of the eye (nystagmus) Problems with movement and balance (ataxia) Other side effects from high doses include unsteadiness in the feet and hands, sleepiness, and vomiting. Phenytoin is a potent inducer of hepatic drug-metabolizing enzymes. Along with its needed effects, a medicine may cause some unwanted effects. osteopenia, osteoporosis, osteomalacia, bone fractures), vitamin D deficiency, hypocalcaemia, hypophosphataemia, acute hepatotoxicity, acute hepatic failure, hypersensitivity, suicidal ideation and behaviour. The most common side effects of phenytoin are headaches and feeling dizzy. Phenytoin. Side effects of phenytoin include sedation, a cerebellar syndrome, phenytoin encephalopathy, psychosis, locomotor dysfunction, hyperkinesia, megaloblastic anemia, decreased serum folate level, decreased bone mineral content, liver disease, IgA deficiency, gingival hyperplasia, and a lupus‐like hypersensitivity syndrome. Tap to unmute. Common side effects that can occur with this drug such as slurred speech, confusion, dizziness, trouble sleeping, problems with walking and coordination, nervousness, tremors, headache, nausea or vomiting, constipation, skin rash. Medically reviewed by Drugs.com. Post published: April 15, 2020; Post Category: Drugs / Mnemonics; Easy to remember mnemonic – PHENYTOIN. Side effects of phenytoin. Hematologic effects reported with use including agranulocytosis, leukopenia, pancytopenia, neutropenia, thrombocytopenia, and anemias. This medicine is an anticonvulsant that works in the brain tissue to stop seizures. These movements often do not interfere with a child's vision. One of its main advantages over benzodiazepines is the less sedative effect. Consumer information about the medication PHENYTOIN - INJECTION (Dilantin), includes side effects, drug interactions, recommended dosages, and storage information. Phenytoin is an established drug in the treatment of acute repetitive seizures and status epilepticus. Phenytoin should be introduced in small dosages with gradual increments until control is achieved or until toxic effects appear. Potentially serious side effects include sleepiness, self harm, liver problems, bone marrow suppression, low blood pressure, and toxic epidermal necrolysis. For commercial use or customized versions, pl Phenytoin may cause swelling and bleeding of the gums. Portions of this document last updated: April 01, 2021. The apparent stimulatory effect has prompted its assessment in wound healing. "Product Information. Dupuytren's contracture and drug rash with eosinophilia and systemic symptoms (DRESS), erythema multiforme, SJS/TEN risk in patients of Asian ancestry who have HLA-B 1502[Ref], Frequency not reported: Decreased serum T4 and FT4, increased serum estradiol levels, gynecomastia, alterations in vitamin D metabolism[Ref], Common (1% to 10%): Tongue disorder, dry mouth, vomiting, constipation, Uncommon (0.1% to 1%): Dyspepsia, diarrhea, anorexia, GI hemorrhage, increased salivation, tenesmus, tongue edema, dysphagia, flatulence, gastritis, ileus, Frequency not reported: Hypoesthesia of the tongue, gingival hyperplasia[Ref], Uncommon (0.1% to 1%): Urinary retention, oliguria, dysuria, vaginitis, albuminuria, genital edema, polyuria, urethral pain, urinary incontinence, vaginal moniliasis, Frequency not reported: Feeling of warmth or tingling in the groin, Peyronie's disease[Ref], Uncommon (0.1% to 1%): Thrombocytopenia, anemia, leukocytosis, cyanosis, hypochromic anemia, leukopenia, lymphadenopathy, petechia, Frequency not reported: Granulocytopenia, agranulocytosis, pancytopenia (with or without bone marrow suppression), aplastic anemia[Ref], Uncommon (0.1% to 1%): Liver function tests abnormal, kidney failure, Frequency not reported: Toxic hepatitis, hepatocellular damage[Ref], Frequency not reported: Hypersensitivity syndrome, periarteritis nodosa, Postmarketing reports: Anaphylactoid reaction, anaphylaxis[Ref], Uncommon (0.1% to 1%): Sepsis, flu syndrome, cryptococcosis, Frequency not reported: Immunoglobulin abnormalities[Ref], Common (1% to 10%): Injection site reaction, injection site pain, Uncommon (0.1% to 1%): Injection site inflammation, injection site edema, injection site hemorrhage[Ref], Uncommon (0.1% to 1%): Generalized edema, cachexia, diabetes insipidus, Frequency not reported: Hyperglycemia, appetite disorder, hypokalemia[Ref], Common (1% to 10%): Back pain, chills, myasthenia, Uncommon (0.1% to 1%): Myopathy, leg cramps, arthralgia, myalgia, muscular weakness, muscle twitching, muscle spasms, Frequency not reported: Systemic lupus erythematosus, polyarthritis, Purple Glove Syndrome[Ref], Very common (10% or more): Nystagmus (59%), dizziness (31%), somnolence (27%), ataxia (18%), Common (1% to 10%): Headache, stupor, incoordination, paresthesia, extrapyramidal syndrome, tremor, vertigo, brain edema, tinnitus, taste perversion (including metallic taste), taste loss, reflexes decreased, reflexes increased, migraine, slurred speech, dysarthria, intracranial hypertension, hyperesthesia, hyporeflexia, Uncommon (0.1% to 1%): Twitching, Babinski sign positive, circumoral paresthesia, hemiplegia, hypotonia, convulsion, meningitis, CNS depression, hypokinesia, hyperkinesia, brain edema, paralysis, aphasia, coma, myoclonus, acute brain syndrome, encephalitis, subdural hematoma, encephalopathy, akathisia, Frequency not reported: CNS depression, dyskinesia (including chorea), dystonia and asterixis similar to those induced by phenothiazines or other neuroleptic drugs, drowsiness, motor twitching, tonic seizures, sensory peripheral polyneuropathy (in patients receiving long-term therapy)[Ref], Common (1% to 10%): Diplopia, amblyopia, blurred vision, visual impairment, Uncommon (0.1% to 1%): Photosensitivity reaction, photophobia, eye pain, mydriasis, visual field defect[Ref], Common (1% to 10%): Asthenia, deafness, accidental injury, fever, face edema, hyperacusis, parosmia, ear pain, Uncommon (0.1% to 1%): Kidney failure[Ref], Uncommon (0.1% to 1%): Pharyngitis, sinusitis, hyperventilation, rhinitis, apnea, aspiration pneumonia, asthma, dyspnea, atelectasis, cough increased, sputum increased, epistaxis, hypoxia, pneumothorax, hemoptysis, bronchitis, Postmarketing reports: Respiratory arrest (sometimes fatal)[Ref], Common (1% to 10%): Agitation, thinking abnormal, nervousness, depression, Uncommon (0.1% to 1%): Confusion, insomnia, depersonalization, psychosis, emotional lability, personality disorder, hostility, amnesia, neurosis, euphoric mood[Ref], 1. (Source: K.D.Tripathi Essentials of Medical Pharmacology 7th Edition) The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You may report side effects to the FDA at 1-800-FDA-1088. Pharmaceutical Society of Australia "APPGuide online. You may report side effects to FDA at 1-800-FDA-1088. All rights reserved. Phenytoin also may affect cognitive functioning at higher levels. See below for a comprehensive list of adverse effects. Phenytoin's inhibitory effect is dependent on the voltage and frequency of neural cell firing by selectively blocking the neurons that are firing at high frequency. sensitivity reaction or a dose related side effects to phenytoin. If you suddenly stop taking phenytoin, your seizures may worsen. 2. However, the possibility of cardiovascular adverse effects with the intravenous use of phenytoin cause a reluctance to its usage, and this has lead to a search for safer anticonvulsant drugs. More information: STITCH, PubChem and possibly Wikipedia. Phenytoin common side effects include dizziness, ataxia, nausea, gum hyperplasia and rash (which can occur in 10% of patients). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. injection which, therefore, must be given under continuous ECG monitoring. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Other side effects from high doses include unsteadiness in the feet and hands, sleepiness, and vomiting. Although not all of these side effects may occur, if they do occur they may need medical attention. Info. Commonly reported side effects of phenytoin include: congenital anomalies. Normal phenytoin level . May render OCPs ineffective because of induction of hepatic metabolism Phenytoin side effects Get emergency medical help if you have signs of an allergic reaction to phenytoin (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering … One last side effect which you should NEVER forget – Fall in BP and cardiac arrhythmias occur only on i.v. Solutions for inj may cause local irritation or phlebitis. The choice between phenytoin and carbamazepine will be influenced by individual needs and responses. Common side effects include nausea, stomach pain, loss of appetite, poor coordination, increased hair growth, and enlargement of the gums. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to phenytoin: compounding powder, injectable solution, oral capsule, oral capsule extended release, oral suspension, oral tablet chewable, Common (1% to 10%): Hypotension, vasodilation, tachycardia, Uncommon (0.1% to 1%): Shock, cardiac arrest, syncope, cerebral hemorrhage, palpitation, sinus bradycardia, atrial flutter, bundle branch block, cardiomegaly, cerebral infarct, postural hypotension, pulmonary embolus, QT interval prolongation, thrombophlebitis, ventricular extrasystoles, congestive heart failure, Frequency not reported: Cardiovascular collapse, severe cardiotoxic reactions with atrial and ventricular conduction depression (including bradycardia and all degrees of heart block), asystole ventricular fibrillation, periarteritis nodosa[Ref], Very common (10% or more): Rash (more serious and rare forms have included bullous, exfoliative or purpuric dermatitis, lupus erythematosus, Stevens-Johnson syndrome and toxic epidermal necrolysis), pruritus, Common (1% to 10%): Maculopapular rash, urticaria, sweating, skin discoloration, contact dermatitis, pustular rash, skin nodule, ecchymosis, Frequency not reported: Hirsutism, hypertrichosis, coarsening of the facial features, enlargement of the lips, Peyronie's disease. These presentations vary from a benign symptom complex, with enlarged lymph nodes, … There have been two placebo-controlled studies in healthy men of the pharmacokinetic interaction of voriconazole with phenytoin [98]. Some side effects can be serious. Hematologic effects reported with use including agranulocytosis, leukopenia, pancytopenia, neutropenia, thrombocytopenia, and anemias. Copy link. All rights reserved. The most common side effects related to Phenytoin in children are jerky movements of the eyes (nystagmus) and overgrowth of the gums. Although not all of these side effects may occur, if they do occur they may need medical attention. More common side effects. Post Author: Med Explosion! It is also used to prevent seizures during or after surgery. If any of these effects remain or worsen, inform your doctor or pharmacist immediately. These may be avoidable if the dosage is increased slowly. Phenytoin has major effects on metabolism of other medications, and patients should be provided specific advice about other medications that can be used during long term phenytoin … License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Like other antiepileptic drugs, phenytoin may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. According to the People's Pharmacy, phenytoin was first discovered in 1908, although it was not used to treat seizure disorders until 1938. Various lymph node abnormalities have been associated with phenytoin therapy. Decreased coordination mental confusion nervousness slurred speech trouble with breathing, speaking, or swallowing unsteadiness, trembling, or other problems with muscle control or coordination Rare. Drug information provided by: IBM Micromedex. Side effects of phenytoin Get emergency medical help if you have signs of an allergic reaction to phenytoin (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that … Phenytoin toxicity as manifested as a syndrome of cerebellar, vestibular, ocular effects, notably nystagmus, diplopia, slurred speech, and ataxia; also with mental confusion, dyskinesias, exacerbations of seizure frequency, hyperglycaemia. Phenytoin Side Effects Headache, nausea, vomiting, constipation, dizziness, feeling of spinning, drowsiness, trouble sleeping, or nervousness may occur. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Phenytoin may help control your condition but will not cure it. Stop receiving CABENUVA and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling Do not stop taking phenytoin without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. Other important side effects caused by phenytoin include sexual dysfunction, such as: decreased libido, impotence, and; priapism (painful, prolonged erections). Our Dilantin (phenytoin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Available from: URL: http://www.appco.com.au/appguide/default.asp." Along with its needed effects, phenytoin may cause some unwanted effects. This medicine is available only with your doctor's prescription. Drug information provided by: IBM Micromedex. Phenytoin Interactions. adverse effect or a serious elect rocardiographic change. Phenytoin can also cause other side effects. In some children, Phenytoin causes problems with thinking or behavior, mood change, slow or clumsy movements, or a loss of energy. Some side effects may not be reported. These are not all the possible side effects of phenytoin. The most common side effects of Phenytoin include slurred speech, problems with coordination, problems with sleeping, confusion, vomiting, dizziness, nervousness and constipations.Most of these are mild symptoms and go away on their own. Some common side effects of phenytoin, such as imbalance, may exacerbate pre-existing problems of seniors, and their greater risk of injury from falls or other accidents makes this an area of concern. Call your doctor for medical advice about side effects. The more common side effects that can occur with phenytoin include: problems … Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Cutaneous side effects are the most common side effects causing discontinuation of carbamazepine; Cross-reaction exists between carbamazepine and amitriptyline; Phenytoin: Erythroderma (redness of the entire skin) Facial pustules (acne medicamentosa) Hyperpigmentation (darkening of the skin) Hypertrichosis (excess hair growth) Lupus-like symptoms Increased risk of suicidal thoughts or behavior reported. Options: Show MedDRA Preferred Terms, display all 25 labels. Other side effects from high doses include unsteadiness in the feet and hands, sleepiness, and vomiting. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.

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